A review of three systemic retinoids in dermatology: acitretin, isotretinoin and bexarotene
نویسندگان
چکیده
Retinoids are synthetic and natural analogues of vitamin A that have various effects on cellular differentiation, cellular proliferation, immune system, and embryonic development. The present study reviews the history of systemic retinoids in medicine, the structure of synthetic retinoids and their mechanisms. The main focus is on their biologic functions, clinical uses, and the adverse effects of isotretinoin, acitretin, and bexarotene representing the most commonly used first, second, and third generation systemic retinoids, respectively.
منابع مشابه
A review of three systemic retinoids in dermatology: acitretin, isotretinoin and bexarotene
Retinoids are synthetic and natural analogues of vitamin A that have various effects on cellular differentiation, cellular proliferation, immune system, and embryonic development. The present study reviews the history of systemic retinoids in medicine, the structure of syn
متن کاملSystemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review.
Hidradenitis suppurativa (HS) is a difficult disease to treat. Although the pathogenesis of this inflammatory skin disease is largely unknown, the important role of the immune system has been demonstrated in both experimental and clinical studies. Clinicians are therefore increasingly prescribing systemic treatments with immunosuppressive agents, but the more traditionally used systemic retinoi...
متن کاملIsotretinoin and Timing of Procedural Interventions: A Systematic Review With Consensus Recommendations.
Importance The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s. Objective To evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions perform...
متن کاملThrombocytopenia probably induced by acitretin.
Retinoids are nonsteroidal hormonal compounds related to retinol. They were discovered more than 50 years ago and have various biologic effects. The oral retinoids currently used in dermatology have different indications and include isotretinoin, acitretin, bexarotene, and alitretinoin. We present the case of a patient who developed thrombocytopenia that was probably induced by acitretin. The p...
متن کاملSynthetic retinoids inhibit the antigen presenting properties of epidermal cells in vitro.
The clinical efficacy of retinoids in benign and malignant skin diseases involving immune mechanisms suggests that they affect the immunologic functions of the epidermis. However, these effects have yet to be demonstrated. The action of vitamin A (retinol) and the synthetic retinoids, isotretinoin, etretinate, acitretin, and arotinoid-free acid have been studied on the lymphocyte proliferation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014